Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition

Neurofibromin 1 (NF1) loss of function (LoF) mutations are frequent in melanoma and drive hyperactivated RAS and tumor growth. NF1(LoF) melanoma cells, however, do not show consistent sensitivity to individual MEK, ERK, or PI3K/mTOR inhibitors. To identify more effective therapeutic strategies for t...

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Detalles Bibliográficos
Autores principales: Abecunas, Cara, Whitehead, Christopher E., Ziemke, Elizabeth K., Baumann, Douglas G., Frankowski-McGregor, Christy L., Sebolt-Leopold, Judith S., Fallahi-Sichani, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845987/
https://www.ncbi.nlm.nih.gov/pubmed/36409827
http://dx.doi.org/10.1158/0008-5472.CAN-22-0883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9845987/
https://www.ncbi.nlm.nih.gov/pubmed/36409827
http://dx.doi.org/10.1158/0008-5472.CAN-22-0883

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