Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells

Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway. We examined whether zoledronic acid can inhibit the growth of osteosarcoma cells by inducing ferro...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Tianhao, Huang, Ju, Sun, Wei, Wang, Guangze, Wu, Yuwen, Jiang, Zewei, Lv, Yingshuai, Wu, Guang, Cao, Jiawei, Liu, Min, Gu, Haihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846057/
https://www.ncbi.nlm.nih.gov/pubmed/36686696
http://dx.doi.org/10.3389/fphar.2022.1071946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846057/
https://www.ncbi.nlm.nih.gov/pubmed/36686696
http://dx.doi.org/10.3389/fphar.2022.1071946

Ejemplares similares