Cargando…

Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells

Aims: Ferroptosis plays important roles in tumorigenesis and cancer therapy. Zoledronic acid is known to inhibit the activity of farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway. We examined whether zoledronic acid can inhibit the growth of osteosarcoma cells by inducing ferro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Tianhao, Huang, Ju, Sun, Wei, Wang, Guangze, Wu, Yuwen, Jiang, Zewei, Lv, Yingshuai, Wu, Guang, Cao, Jiawei, Liu, Min, Gu, Haihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846057/ https://www.ncbi.nlm.nih.gov/pubmed/36686696 http://dx.doi.org/10.3389/fphar.2022.1071946

Ejemplares similares

Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells
por: Lai, Xingrong, et al.
Publicado: (2022)

Identification of HMOX1 as a Critical Ferroptosis-Related Gene in Atherosclerosis
por: Wu, Daiqian, et al.
Publicado: (2022)

Exploring the role of Hmox1 in ferroptosis and immune infiltration during renal ischemia-reperfusion injury
por: Luo, Jin, et al.
Publicado: (2023)

Identifying therapeutic biomarkers of zoledronic acid by metabolomics
por: Li, Xiang, et al.
Publicado: (2023)

Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1
por: Meng, Peina, et al.
Publicado: (2023)

MTHFR inhibits TRC8‐mediated HMOX1 ubiquitination and regulates ferroptosis in ovarian cancer
por: Wang, Xiang, et al.
Publicado: (2022)

Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1
por: Li, Shishi, et al.
Publicado: (2021)

USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α
por: Cao, Jiawei, et al.
Publicado: (2021)

Isoliquiritigenin induces HMOX1 and GPX4-mediated ferroptosis in gallbladder cancer cells
por: Wang, Zeyu, et al.
Publicado: (2023)

Therapeutic effect of a MUC1-specific monoclonal antibody-drug conjugates against pancreatic cancer model
por: Wu, Guang, et al.
Publicado: (2022)

SPHK Inhibitors and Zoledronic Acid Suppress Osteoclastogenesis and Wear Particle-Induced Osteolysis
por: Gu, Minghui, et al.
Publicado: (2022)

Cost-Effectiveness of Sequential Denosumab/Zoledronic Acid Compared With Zoledronic Acid Monotherapy for Postmenopausal Osteoporotic Women in China
por: You, Ruxu, et al.
Publicado: (2022)

Donafenib and GSK‐J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression
por: Zheng, Chenyang, et al.
Publicado: (2023)

RegB Kinase Activity Is Controlled in Part by Monitoring the Ratio of Oxidized to Reduced Ubiquinones in the Ubiquinone Pool
por: Wu, Jiang, et al.
Publicado: (2010)

How zoledronic acid improves osteoporosis by acting on osteoclasts
por: Wang, Biao, et al.
Publicado: (2022)

The mechanism of the Nfe2l2/Hmox1 signaling pathway in ferroptosis regulation in acute compartment syndrome
por: Zheng, Tiejun, et al.
Publicado: (2022)

Cost-Effectiveness of Zoledronic Acid Versus Oral Alendronate for Postmenopausal Osteoporotic Women in China
por: You, Ruxu, et al.
Publicado: (2020)

Zoledronic acid is an effective radiosensitizer in the treatment of osteosarcoma
por: Kim, Eun Ho, et al.
Publicado: (2016)

Mechanism of sorafenib resistance associated with ferroptosis in HCC
por: Guo, Lingling, et al.
Publicado: (2023)

The Mechanism of Ferroptosis and Applications in Tumor Treatment
por: Lin, Xinyue, et al.
Publicado: (2020)

Vitamin C Sensitizes Pancreatic Cancer Cells to Erastin-Induced Ferroptosis by Activating the AMPK/Nrf2/HMOX1 Pathway
por: Liu, Yawen, et al.
Publicado: (2022)

HMOX1 Promotes Ferroptosis in Mammary Epithelial Cells via FTH1 and Is Involved in the Development of Clinical Mastitis in Dairy Cows
por: Zhang, Quanwei, et al.
Publicado: (2022)

Identification of two novel ferroptosis-associated targets in sepsis-induced cardiac injury: Hmox1 and Slc7a11
por: Xu, Yushun, et al.
Publicado: (2023)

Doxofylline ameliorates liver fibrosis by regulating the ferroptosis signaling pathway
por: Xu, Lenan, et al.
Publicado: (2023)

Indication and adverse event profiles of denosumab and zoledronic acid: based on U.S. FDA adverse event reporting system (FAERS)
por: Su, Si, et al.
Publicado: (2023)

Targeting ferroptosis as novel therapeutic approaches for epilepsy
por: Jin, Yuzi, et al.
Publicado: (2023)

Targeting ferroptosis in osteosarcoma
por: Zhao, Jiazheng, et al.
Publicado: (2021)

Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
por: Zhang, Xiaoli, et al.
Publicado: (2023)

Ferroptosis: A mixed blessing for infectious diseases
por: Xiao, Leyao, et al.
Publicado: (2022)

Reduction of Hydrophilic Ubiquinones by the Flavin in Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) and Production of Reactive Oxygen Species
por: King, Martin S., et al.
Publicado: (2009)

Targeting Ferroptosis Pathway to Combat Therapy Resistance and Metastasis of Cancer
por: Liu, Xuan, et al.
Publicado: (2022)

The Role of Ferroptosis in Cancer Development and Treatment Response
por: Lu, Bin, et al.
Publicado: (2018)

Zoledronate‐Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma
por: Lundberg, A.P., et al.
Publicado: (2016)

Ferroptosis as an emerging therapeutic target in liver diseases
por: Lu, Yuzhen, et al.
Publicado: (2023)

Zoledronic Acid Targeting of the Mevalonate Pathway Causes Reduced Cell Recruitment and Attenuates Pulmonary Fibrosis
por: Tanner, Lloyd, et al.
Publicado: (2022)

Optimization of the dosage regimen of zoledronic acid with a kinetic-pharmacodynamic model and exposure-response analysis
por: Wang, Huan, et al.
Publicado: (2023)

Molecular mechanisms of ferroptosis and the potential therapeutic targets of ferroptosis signaling pathways for glioblastoma
por: Zhang, Meng, et al.
Publicado: (2022)

Potential targets and applications of nanodrug targeting myeloid cells in osteosarcoma for the enhancement of immunotherapy
por: Zhu, Jianshu, et al.
Publicado: (2023)

Targeting ferroptosis, the achilles’ heel of breast cancer: A review
por: Liu, Yang, et al.
Publicado: (2022)

Ferroptosis-related genes are involved in asthma and regulate the immune microenvironment
por: Wang, Haixia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pcmoouqllic0i854japmp0p725