Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells

In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Ya-Sai, Wang, Zi-Wei, Gao, Zhe, Zhao, Wen, Thakur, Kiran, Zhong, Qian, Wei, Zhao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846341/
https://www.ncbi.nlm.nih.gov/pubmed/36686366
http://dx.doi.org/10.1016/j.crfs.2022.05.009
_version_ 1784871156825718784
author Sun, Ya-Sai
Wang, Zi-Wei
Gao, Zhe
Zhao, Wen
Thakur, Kiran
Zhong, Qian
Wei, Zhao-Jun
author_facet Sun, Ya-Sai
Wang, Zi-Wei
Gao, Zhe
Zhao, Wen
Thakur, Kiran
Zhong, Qian
Wei, Zhao-Jun
author_sort Sun, Ya-Sai
collection PubMed
description In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients.
format Online
Article
Text
id pubmed-9846341
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-98463412023-01-19 Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells Sun, Ya-Sai Wang, Zi-Wei Gao, Zhe Zhao, Wen Thakur, Kiran Zhong, Qian Wei, Zhao-Jun Curr Res Food Sci Research Paper In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients. Elsevier 2022-05-29 /pmc/articles/PMC9846341/ /pubmed/36686366 http://dx.doi.org/10.1016/j.crfs.2022.05.009 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Sun, Ya-Sai
Wang, Zi-Wei
Gao, Zhe
Zhao, Wen
Thakur, Kiran
Zhong, Qian
Wei, Zhao-Jun
Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
title Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
title_full Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
title_fullStr Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
title_full_unstemmed Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
title_short Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells
title_sort proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on hct116 cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846341/
https://www.ncbi.nlm.nih.gov/pubmed/36686366
http://dx.doi.org/10.1016/j.crfs.2022.05.009
work_keys_str_mv AT sunyasai proanthocyanidinoligomersextractfromhawthornmediatescellcyclearrestapoptosisandlysosomevacuolationonhct116cells
AT wangziwei proanthocyanidinoligomersextractfromhawthornmediatescellcyclearrestapoptosisandlysosomevacuolationonhct116cells
AT gaozhe proanthocyanidinoligomersextractfromhawthornmediatescellcyclearrestapoptosisandlysosomevacuolationonhct116cells
AT zhaowen proanthocyanidinoligomersextractfromhawthornmediatescellcyclearrestapoptosisandlysosomevacuolationonhct116cells
AT thakurkiran proanthocyanidinoligomersextractfromhawthornmediatescellcyclearrestapoptosisandlysosomevacuolationonhct116cells
AT zhongqian proanthocyanidinoligomersextractfromhawthornmediatescellcyclearrestapoptosisandlysosomevacuolationonhct116cells
AT weizhaojun proanthocyanidinoligomersextractfromhawthornmediatescellcyclearrestapoptosisandlysosomevacuolationonhct116cells

Ejemplares similares