Evolutionary analysis of p38 stress-activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress

p38 kinases are key elements of the cellular stress response in animals. They mediate the cell response to a multitude of stress stimuli, from osmotic shock to inflammation and oncogenes. However, it is unknown how such diversity of function in stress evolved in this kinase subfamily. Here, we show...

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Detalles Bibliográficos
Autores principales: Shabardina, Victoria, Charria, Pedro Romero, Saborido, Gonzalo Bercedo, Diaz-Mora, Ester, Cuenda, Ana, Ruiz-Trillo, Iñaki, Sanz-Ezquerro, Juan Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846432/
https://www.ncbi.nlm.nih.gov/pubmed/36651171
http://dx.doi.org/10.1098/rsob.220314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846432/
https://www.ncbi.nlm.nih.gov/pubmed/36651171
http://dx.doi.org/10.1098/rsob.220314

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