Cargando…
Fundamentals to therapeutics: Epigenetic modulation of CD8(+) T Cell exhaustion in the tumor microenvironment
In the setting of chronic antigen exposure in the tumor microenvironment (TME), cytotoxic CD8(+) T cells (CTLs) lose their immune surveillance capabilities and ability to clear tumor cells as a result of their differentiation into terminally exhausted CD8(+) T cells. Immune checkpoint blockade (ICB)...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846628/ https://www.ncbi.nlm.nih.gov/pubmed/36684449 http://dx.doi.org/10.3389/fcell.2022.1082195 |