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Unravelling the instability of mutational signatures extraction via archetypal analysis

The high cosine similarity between some single-base substitution mutational signatures and their characteristic flat profiles could suggest the presence of overfitting and mathematical artefacts. The newest version (v3.3) of the signature database available in the Catalogue Of Somatic Mutations In C...

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Detalles Bibliográficos
Autores principales: Pancotti, Corrado, Rollo, Cesare, Birolo, Giovanni, Benevenuta, Silvia, Fariselli, Piero, Sanavia, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846778/
https://www.ncbi.nlm.nih.gov/pubmed/36685831
http://dx.doi.org/10.3389/fgene.2022.1049501