Cargando…

Payload diversification: a key step in the development of antibody–drug conjugates

Antibody–drug conjugates (ADCs) is a fast moving class of targeted biotherapeutics that currently combines the selectivity of monoclonal antibodies with the potency of a payload consisting of cytotoxic agents. For many years microtubule targeting and DNA-intercalating agents were at the forefront of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conilh, Louise, Sadilkova, Lenka, Viricel, Warren, Dumontet, Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847035/ https://www.ncbi.nlm.nih.gov/pubmed/36650546 http://dx.doi.org/10.1186/s13045-022-01397-y

Ejemplares similares

Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform
por: Conilh, Louise, et al.
Publicado: (2021)

Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates
por: Viricel, Warren, et al.
Publicado: (2019)

Antibody–drug conjugates: Recent advances in payloads
por: Wang, Zhijia, et al.
Publicado: (2023)

Antibody-Drug Conjugates Containing Payloads from Marine Origin
por: Cheng-Sánchez, Iván, et al.
Publicado: (2022)

Challenges and opportunities to develop enediyne natural products as payloads for antibody-drug conjugates
por: Adhikari, Ajeeth, et al.
Publicado: (2021)

Site-Specific Antibody Conjugation with Payloads beyond Cytotoxins
por: Zhou, Qun
Publicado: (2023)

Antibody-Drug Conjugates in Solid Tumor Oncology: An Effectiveness Payday with a Targeted Payload
por: Kondrashov, Aleksei, et al.
Publicado: (2023)

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates
por: Karpov, Alexei S., et al.
Publicado: (2018)

Disulfide re-bridging reagents for single-payload antibody-drug conjugates
por: King, Thomas A., et al.
Publicado: (2023)

Antibody–Drug Conjugates: The Last Decade
por: Joubert, Nicolas, et al.
Publicado: (2020)

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
por: Yamazaki, Chisato M., et al.
Publicado: (2021)

Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload
por: Wang, Yanming, et al.
Publicado: (2017)

Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility
por: Satomaa, Tero, et al.
Publicado: (2018)

Antibody–Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization
por: Buongervino, Samantha, et al.
Publicado: (2021)

A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy
por: Böhnke, Niels, et al.
Publicado: (2022)

Chemotherapy payload of anti-insoluble fibrin antibody-drug conjugate is released specifically upon binding to fibrin
por: Fuchigami, Hirobumi, et al.
Publicado: (2018)

Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology
por: de Bever, Laureen, et al.
Publicado: (2023)

Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release
por: Quintana, Jeremy M., et al.
Publicado: (2022)

Antibody-Drug Conjugate Using Ionized Cys-Linker-MMAE as the Potent Payload Shows Optimal Therapeutic Safety
por: Wang, Yanming, et al.
Publicado: (2020)

Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency
por: Su, Dian, et al.
Publicado: (2021)

Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process
por: Lehot, Victor, et al.
Publicado: (2023)

Automated linkage of proteins and payloads producing monodisperse conjugates
por: Dovgan, Igor, et al.
Publicado: (2020)

Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors
por: Lipovšek, Daša, et al.
Publicado: (2018)

Microbubble–liposome conjugate: Payload evaluation of potential theranostic vehicle
por: Malik, Ritu, et al.
Publicado: (2016)

Facile protein conjugation of platinum for light-activated cytotoxic payload release
por: Imberti, Cinzia, et al.
Publicado: (2021)

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
por: Hartley, John A., et al.
Publicado: (2018)

Characterization of T‐DM1‐resistant breast cancer cells
por: Sauveur, Juliette, et al.
Publicado: (2020)

High drug payload nanoparticles formed from dexamethasone-peptide conjugates for the treatment of endotoxin-induced uveitis in rabbit
por: Yu, Xinxin, et al.
Publicado: (2019)

Antitumor activity of a 5T4 targeting antibody drug conjugate with a novel payload derived from MMAF via C‐Lock linker
por: Shi, Baoying, et al.
Publicado: (2019)

A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma
por: Hoffmann, Ricarda M., et al.
Publicado: (2020)

Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates
por: Dugal-Tessier, Julien, et al.
Publicado: (2021)

Development of a Single-Step Antibody–Drug Conjugate Purification Process with Membrane Chromatography
por: Cordova, Juan Carlos, et al.
Publicado: (2021)

Evolution of the Computational Pharmaceutics Approaches in the Modeling and Prediction of Drug Payload in Lipid and Polymeric Nanocarriers
por: Abd-algaleel, Shaymaa A., et al.
Publicado: (2021)

Trends in the Development of Antibody-Drug Conjugates for Cancer Therapy
por: Song, Chi Hun, et al.
Publicado: (2023)

IL3RA-Targeting Antibody–Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies
por: Kirchhoff, Dennis, et al.
Publicado: (2020)

Sperm RNA Payload: Implications for Intergenerational Epigenetic Inheritance
por: Liu, Simeiyun, et al.
Publicado: (2023)

Huygens: science, payload and mission
por: Wilson, A
Publicado: (1997)

Satellite communications payload and system
por: Braun, T M
Publicado: (2012)

Introduction to Antibody-Drug Conjugates
por: Pettinato, Mark C.
Publicado: (2021)

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates
por: Kamath, Amrita V., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_nh7aoo9ggssmanbpljplvc08tq