Genomic Profiling Reveals Differences in Primary Central Nervous System Lymphoma and Large B-Cell Lymphoma, With Subtyping Suggesting Sensitivity to BTK Inhibition

BACKGROUND: B-cell primary central nervous system (CNS) lymphoma (PCL) is diffuse large B-cell lymphoma (DLBCL) confined to the CNS. Less than 50% of patients with PCL achieve complete remission with current therapies. We describe the findings from comprehensive genomic profiling (CGP) of a cohort o...

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Detalles Bibliográficos
Autores principales: Severson, Eric A, Haberberger, James, Hemmerich, Amanda, Huang, Richard S P, Edgerly, Claire, Schiavone, Kelsie, Najafian, Adib, Hiemenz, Matthew, Lechpammer, Mirna, Vergilio, Jo-Anne, Lesser, Glenn, Strowd, Roy, Elvin, Julia, Ross, Jeffrey S, Hegde, Priti, Alexander, Brian, Singer, Samuel, Ramkissoon, Shakti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Hematologic Malignancies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847534/
https://www.ncbi.nlm.nih.gov/pubmed/36342081
http://dx.doi.org/10.1093/oncolo/oyac190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9847534/
https://www.ncbi.nlm.nih.gov/pubmed/36342081
http://dx.doi.org/10.1093/oncolo/oyac190

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