Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators

In this research, two novel series of dibenzo[b,f]azepines (14 candidates) were designed and synthesised based on the rigidification principle and following the reported doxorubicin’s pharmacophoric features. The anti-proliferative activity was evaluated at the NCI against a panel of 60 cancer cell...

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Detalles Bibliográficos
Autores principales: El-Behairy, Mohammed Farrag, Abd-Allah, Walaa Hamada, Khalifa, Mohamed M., Nafie, Mohamed S., Saleh, Mohamed A., Abdel-Maksoud, Mohammed S., Al-Warhi, Tarfah, Eldehna, Wagdy M., Al‐Karmalawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848257/
https://www.ncbi.nlm.nih.gov/pubmed/36629421
http://dx.doi.org/10.1080/14756366.2022.2157825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848257/
https://www.ncbi.nlm.nih.gov/pubmed/36629421
http://dx.doi.org/10.1080/14756366.2022.2157825

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