Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation

The colchicine binding site of tubulin is a promising target for discovering novel antitumour agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate tubulin polymerisation inhibitory activity and broad-spectrum in vitro antitumour activity. In this study, structure...

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Detalles Bibliográficos
Autores principales: Liu, Wei, He, Youyou, Guo, Zhongjie, Wang, Miaomiao, Han, Xiaodong, Jia, Hairui, He, Jin, Miao, Shanshan, Wang, Shengzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848350/
https://www.ncbi.nlm.nih.gov/pubmed/36629423
http://dx.doi.org/10.1080/14756366.2022.2155815

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848350/
https://www.ncbi.nlm.nih.gov/pubmed/36629423
http://dx.doi.org/10.1080/14756366.2022.2155815

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