Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities

New quinoline-pyridine hybrids were designed and synthesised as PIM-1/2 kinase inhibitors. Compounds 5b, 5c, 6e, 13a, 13c, and 14a showed in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (...

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Detalles Bibliográficos
Autores principales: El-Miligy, Mostafa M. M., Abdelaziz, Marwa E., Fahmy, Salwa M., Ibrahim, Tamer M., Abu-Serie, Marwa M., Mahran, Mona A., Hazzaa, Aly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848351/
https://www.ncbi.nlm.nih.gov/pubmed/36629075
http://dx.doi.org/10.1080/14756366.2022.2152810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848351/
https://www.ncbi.nlm.nih.gov/pubmed/36629075
http://dx.doi.org/10.1080/14756366.2022.2152810

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