Cargando…

The structure of DarB in complex with Rel(NTD) reveals nonribosomal activation of Rel stringent factors

Rel stringent factors are bifunctional ribosome-associated enzymes that catalyze both synthesis and hydrolysis of the alarmones (p)ppGpp. Besides the allosteric control by starved ribosomes and (p)ppGpp, Rel is regulated by various protein factors depending on specific stress conditions, including t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ainelo, Andres, Caballero-Montes, Julien, Bulvas, Ondřej, Ernits, Karin, Coppieters ‘t Wallant, Kyo, Takada, Hiraku, Craig, Sophie Z., Mazzucchelli, Gabriel, Zedek, Safia, Pichová, Iva, Atkinson, Gemma C., Talavera, Ariel, Martens, Chloe, Hauryliuk, Vasili, Garcia-Pino, Abel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848473/ https://www.ncbi.nlm.nih.gov/pubmed/36652515 http://dx.doi.org/10.1126/sciadv.ade4077

Ejemplares similares

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA
por: Turnbull, Kathryn Jane, et al.
Publicado: (2019)

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis
por: Arenz, Stefan, et al.
Publicado: (2016)

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA
por: Kudrin, Pavel, et al.
Publicado: (2018)

Biochemical and X-ray analyses of the players involved in the faRel2/aTfaRel2 toxin–antitoxin operon
por: Dominguez-Molina, Lucia, et al.
Publicado: (2023)

Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis
por: Takada, Hiraku, et al.
Publicado: (2020)

Structural basis for c-di-AMP–dependent regulation of the bacterial stringent response by receptor protein DarB
por: Heidemann, Jana L., et al.
Publicado: (2022)

Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams
por: Kudrin, Pavel, et al.
Publicado: (2017)

Positive Feedback and Noise Activate the Stringent Response Regulator Rel in Mycobacteria
por: Sureka, Kamakshi, et al.
Publicado: (2008)

Ribosome•RelA structures reveal the mechanism of stringent response activation
por: Loveland, Anna B, et al.
Publicado: (2016)

Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint
por: Tamman, Hedvig, et al.
Publicado: (2022)

NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
por: Kabacaoglu, Derya, et al.
Publicado: (2019)

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life
por: Atkinson, Gemma C., et al.
Publicado: (2011)

NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
por: Léger, Loïc, et al.
Publicado: (2021)

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes
por: Takada, Hiraku, et al.
Publicado: (2020)

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor
por: Beljantseva, Jelena, et al.
Publicado: (2017)

RelB and Neuroinflammation
por: Mockenhaupt, Karli, et al.
Publicado: (2021)

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB
por: Overgaard, Martin, et al.
Publicado: (2009)

Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ
por: Steinchen, Wieland, et al.
Publicado: (2018)

Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma
por: Li, Ling, et al.
Publicado: (2015)

Cationic bactericidal peptide 1018 does not specifically target the stringent response alarmone (p)ppGpp
por: Andresen, Liis, et al.
Publicado: (2016)

Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p)ppGpp synthase
por: Brockmann-Gretza, Olaf, et al.
Publicado: (2006)

The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation
por: Drecktrah, Dan, et al.
Publicado: (2015)

Correction: The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation
por: Drecktrah, Dan, et al.
Publicado: (2015)

Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts
por: Lovas, Agnes, et al.
Publicado: (2008)

Borrelia [bә-rel′e-ә]
Publicado: (2009)

Influence of the relA gene on ribosome frameshifting
por: Masucci, J., et al.
Publicado: (2002)

Cell transformation by v-Rel reveals distinct roles of AP-1 family members in Rel/NF-κB oncogenesis
por: Liss, Andrew S., et al.
Publicado: (2010)

Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA
por: Kochupurakkal, Bose S., et al.
Publicado: (2015)

Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli
por: Varik, Vallo, et al.
Publicado: (2016)

Myb proteins inhibit fibroblast transformation by v-Rel
por: Fu, Shu-ling, et al.
Publicado: (2006)

The Significance of EXDD and RXKD Motif Conservation in Rel Proteins
por: Sajish, Mathew, et al.
Publicado: (2009)

relA Enhances the Adherence of Enteropathogenic Escherichia coli
por: Spira, Beny, et al.
Publicado: (2014)

Association of REL polymorphisms and outcome of patients with septic shock
por: Toubiana, Julie, et al.
Publicado: (2016)

Rel Is Required for Morphogenesis of Resting Cells in Mycobacterium smegmatis
por: Wu, Mu-Lu, et al.
Publicado: (2016)

The Unsolved Puzzle of c-Rel in B Cell Lymphoma
por: Kober-Hasslacher, Maike, et al.
Publicado: (2019)

The mitochondrial localization of RelB and NFATx in immature T cells
por: Stasik, Izabela, et al.
Publicado: (2008)

RelB regulates the homeostatic proliferation but not the function of Tregs
por: Zhou, Shuping, et al.
Publicado: (2020)

relA Inactivation Converts Sulfonamides Into Bactericidal Compounds
por: Si, Lizhen, et al.
Publicado: (2021)

Small Alarmone Synthetases RelP and RelQ of Staphylococcus aureus Are Involved in Biofilm Formation and Maintenance Under Cell Wall Stress Conditions
por: Salzer, Andrea, et al.
Publicado: (2020)

Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors
por: Andresen, Liis, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gr38uir4qj8po4usiksidsmh5g