Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels

The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na(+) channel (ENaC) play essential roles in transepithelial ion and fluid transport in numerous epithelial tissues. Inhibitors of both channels have been important tools for defining their physiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, JinHeng, Gettings, Sean M., Talbi, Khaoula, Schreiber, Rainer, Taggart, Michael J., Preller, Matthias, Kunzelmann, Karl, Althaus, Mike, Gray, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Ion Channels, Receptors and Transporters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849171/
https://www.ncbi.nlm.nih.gov/pubmed/36205782
http://dx.doi.org/10.1007/s00424-022-02758-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849171/
https://www.ncbi.nlm.nih.gov/pubmed/36205782
http://dx.doi.org/10.1007/s00424-022-02758-9

Ejemplares similares