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Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels

The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na(+) channel (ENaC) play essential roles in transepithelial ion and fluid transport in numerous epithelial tissues. Inhibitors of both channels have been important tools for defining their physiological...

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Detalles Bibliográficos
Autores principales:	Lin, JinHeng, Gettings, Sean M., Talbi, Khaoula, Schreiber, Rainer, Taggart, Michael J., Preller, Matthias, Kunzelmann, Karl, Althaus, Mike, Gray, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Ion Channels, Receptors and Transporters
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849171/ https://www.ncbi.nlm.nih.gov/pubmed/36205782 http://dx.doi.org/10.1007/s00424-022-02758-9

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