HDAC1 disrupts the tricarboxylic acid (TCA) cycle through the deacetylation of Nur77 and promotes inflammation in ischemia-reperfusion mice

Histone deacetylase enzymes (HDACs) regulate protein acetylation. HDAC1 is known to enhance ischemia/reperfusion (I/R) injury, but its underlying mechanism(s) of action have not been defined. Here, in vivo mouse models of myocardial I/R were used to investigate the role of HDAC1 during I/R myocardia...

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Detalles Bibliográficos
Autores principales: Wu, Zhenhua, Bai, Yunpeng, Qi, Yujuan, Chang, Chao, Jiao, Yan, Bai, Yaobang, Guo, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849262/
https://www.ncbi.nlm.nih.gov/pubmed/36653355
http://dx.doi.org/10.1038/s41420-023-01308-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849262/
https://www.ncbi.nlm.nih.gov/pubmed/36653355
http://dx.doi.org/10.1038/s41420-023-01308-1

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