Cargando…
Detection of antibodies against the huntingtin protein in human plasma
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder resulting from a CAG expansion in the huntingtin (HTT) gene, which leads to the production and accumulation of mutant huntingtin (mHTT). While primarily considered a disorder of the central nervous system, multiple change...
Autores principales: | Denis, Hélèna L., Alpaugh, Melanie, Alvarez, Claudia P., Fenyi, Alexis, Barker, Roger A., Chouinard, Sylvain, Arrowsmith, Cheryl H., Melki, Ronald, Labib, Richard, Harding, Rachel J., Cicchetti, Francesca |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849309/ https://www.ncbi.nlm.nih.gov/pubmed/36651994 http://dx.doi.org/10.1007/s00018-023-04687-x |
Ejemplares similares
-
Demonstration of prion-like properties of mutant huntingtin fibrils in both in vitro and in vivo paradigms
por: Masnata, Maria, et al.
Publicado: (2019) -
Correction to: Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders
por: de Rus Jacquet, Aurélie, et al.
Publicado: (2021) -
The troubling story of blood-driven dementias
por: Rieux, Marie, et al.
Publicado: (2018) -
The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications
por: Masnata, Maria, et al.
Publicado: (2017) -
α-Synuclein and huntingtin exon 1 amyloid fibrils bind laterally to the cellular membrane
por: Monsellier, Elodie, et al.
Publicado: (2016)