Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway

The type I cGMP-dependent protein kinase (PKG I) is recognized as a tumor suppressor, but its role in EGFR regulated epithelial ovarian cancer (EOC) progression remains unclear. We evaluated the in vivo and in vitro effects of activated PKG I in EGF-induced EOC cell proliferation, migration, and inv...

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Detalles Bibliográficos
Autores principales: Lan, Ting, Li, Ying, Wang, Yue, Wang, Zhong-Cheng, Mu, Chun-Yan, Tao, Ai-Bin, Gong, Jian-Li, Zhou, Yuan, Xu, Hao, Li, Shi-Bao, Gu, Bing, Ma, Ping, Luo, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849337/
https://www.ncbi.nlm.nih.gov/pubmed/36653376
http://dx.doi.org/10.1038/s41419-023-05580-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849337/
https://www.ncbi.nlm.nih.gov/pubmed/36653376
http://dx.doi.org/10.1038/s41419-023-05580-y

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