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Challenges in predicting stabilizing variations: An exploration

An open challenge of computational and experimental biology is understanding the impact of non-synonymous DNA variations on protein function and, subsequently, human health. The effects of these variants on protein stability can be measured as the difference in the free energy of unfolding (ΔΔG) bet...

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Detalles Bibliográficos
Autores principales: Benevenuta, Silvia, Birolo, Giovanni, Sanavia, Tiziana, Capriotti, Emidio, Fariselli, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849384/
https://www.ncbi.nlm.nih.gov/pubmed/36685278
http://dx.doi.org/10.3389/fmolb.2022.1075570