Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome

Myxomatous valve disease (MVD) can lead to cardiac dysfunction and heart failure, yet medical therapies are lacking. C-C chemokine receptor type 2 (CCR2)+ immune cell infiltration promotes mitral valve inflammation in a Marfan syndrome (MFS) mouse model. The CCR2 genetic knockout reduces inflammatio...

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Detalles Bibliográficos
Autores principales: Xu, Na, Yutzey, Katherine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849467/
https://www.ncbi.nlm.nih.gov/pubmed/36687269
http://dx.doi.org/10.1016/j.jacbts.2022.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849467/
https://www.ncbi.nlm.nih.gov/pubmed/36687269
http://dx.doi.org/10.1016/j.jacbts.2022.06.001

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