Chemically diverse activity-based probes with unexpected inhibitory mechanisms targeting trypsin-like serine proteases

Activity-based probes (ABP) are molecules that bind covalently to the active form of an enzyme family, making them an attractive tool for target and biomarker identification and drug discovery. The present study describes the synthesis and biochemical characterization of novel activity-based probes...

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Detalles Bibliográficos
Autores principales: Ramos-Llorca, Alba, Decraecker, Lisse, Cacheux, Valérie M. Y., Zeiburlina, Irena, De bruyn, Michelle, Battut, Louise, Moreno-Cinos, Carlos, Ceradini, Davide, Espinosa, Eric, Dietrich, Gilles, Berg, Maya, De Meester, Ingrid, Van Der Veken, Pieter, Boeckxstaens, Guy, Lambeir, Anne-Marie, Denadai-Souza, Alexandre, Augustyns, Koen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849758/
https://www.ncbi.nlm.nih.gov/pubmed/36688031
http://dx.doi.org/10.3389/fchem.2022.1089959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849758/
https://www.ncbi.nlm.nih.gov/pubmed/36688031
http://dx.doi.org/10.3389/fchem.2022.1089959

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