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Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons

Motor neuron (MN) diseases, including amyotrophic lateral sclerosis, progressive bulbar palsy, primary lateral sclerosis and spinal muscular atrophy, cause progressive paralysis and, in many cases, death. A better understanding of the molecular mechanisms of pathogenesis is urgently needed to identi...

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Detalles Bibliográficos
Autores principales: Castillo Bautista, Cristina Marisol, Sterneckert, Jared
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9849822/
https://www.ncbi.nlm.nih.gov/pubmed/36684437
http://dx.doi.org/10.3389/fcell.2022.1089970