Cargando…

EBV LMP1-C terminal binding affibody molecule downregulates MEK/ERK/p90RSK pathway and inhibits the proliferation of nasopharyngeal carcinoma cells in mouse tumor xenograft models

Nasopharyngeal carcinoma (NPC), is an Epstein-Barr virus (EBV) associated malignancy most common in Southern China and Southeast Asia. In southern China, it is one of the major causes of cancer-related death. Despite improvement in radiotherapy and chemotherapy techniques, locoregional recurrence an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Yanru, Kamara, Saidu, Zhang, Jing, Wen, He, Zheng, Maolin, Liu, Ying, Zhou, Luqi, Chen, Jun, Zhu, Shanli, Zhang, Lifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850235/ https://www.ncbi.nlm.nih.gov/pubmed/36683690 http://dx.doi.org/10.3389/fcimb.2022.1078504

Ejemplares similares

Novel Bifunctional Affibody Molecules with Specific Binding to Both EBV LMP1 and LMP2 for Targeted Therapy of Nasopharyngeal Carcinoma
por: Kamara, Saidu, et al.
Publicado: (2023)

Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma
por: Zhu, Shanli, et al.
Publicado: (2020)

Generation of novel affibody molecules targeting the EBV LMP2A N-terminal domain with inhibiting effects on the proliferation of nasopharyngeal carcinoma cells
por: Zhu, Jinshun, et al.
Publicado: (2020)

Correction: Generation of novel affibody molecules targeting the EBV LMP2A N-terminal domain with inhibiting effects on the proliferation of nasopharyngeal carcinoma cells
por: Zhu, Jinshun, et al.
Publicado: (2020)

Novel Affibody Molecules Specifically Bind to SARS-CoV-2 Spike Protein and Efficiently Neutralize Delta and Omicron Variants
por: Du, Wangqi, et al.
Publicado: (2022)

Novel Affibody Molecules Targeting the HPV16 E6 Oncoprotein Inhibited the Proliferation of Cervical Cancer Cells
por: Zhu, Jinshun, et al.
Publicado: (2021)

A Therapeutic Approach to Nasopharyngeal Carcinomas by DNAzymes Targeting EBV LMP-1 Gene
por: Yang, Lifang, et al.
Publicado: (2010)

Identification and characterization of novel B-cell epitopes within EBV latent membrane protein 2 (LMP2)
por: Xue, Xiangyang, et al.
Publicado: (2011)

EBV-LMP1 promotes radioresistance by inducing protective autophagy through BNIP3 in nasopharyngeal carcinoma
por: Xu, San, et al.
Publicado: (2021)

HSV-tk/GCV gene therapy mediated by EBV-LMP1 for EBV-associated cancer
por: Lifang, Yang, et al.
Publicado: (2008)

Differential expression of EBV proteins LMP1 and BHFR1 in EBV-associated gastric and nasopharyngeal cancer tissues
por: WANG, AILIANG, et al.
Publicado: (2016)

EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer
por: Wakae, Kousho, et al.
Publicado: (2020)

LMP1-EBV Gene Deletion Mutations and HLA Genotypes of Nasopharyngeal Cancer Patients in Vietnam
por: Trinh, Cua Thi Hong, et al.
Publicado: (2023)

The EBV-Encoded Oncoprotein, LMP1, Recruits and Transforms Fibroblasts via an ERK-MAPK-Dependent Mechanism
por: Davis, Alexandra M, et al.
Publicado: (2021)

Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma
por: Wang, Zifeng, et al.
Publicado: (2016)

Preclinical study of LMP1-RNAi-based anti-tumor therapy in EBV-positive nasopharyngeal carcinoma
por: Yuan, Qi, et al.
Publicado: (2023)

Generating CTLs against the subdominant EBV LMP antigens by transit expression of an A20 inhibitor with EBV LMP proteins in human DCs
por: Hong, Bangxing, et al.
Publicado: (2011)

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma
por: Yang, Lifang, et al.
Publicado: (2015)

New Look of EBV LMP1 Signaling Landscape
por: Wang, Ling, et al.
Publicado: (2021)

Generation of a novel affibody molecule targeting Chlamydia trachomatis MOMP
por: Li, Mingyang, et al.
Publicado: (2021)

Cancer-Associated Fibroblasts in Undifferentiated Nasopharyngeal Carcinoma: A Putative Role for the EBV-Encoded Oncoprotein, LMP1
por: Morris, Mhairi A.
Publicado: (2019)

Molecular Screening for Epstein-Barr virus (EBV): Detection of Genomic EBNA-1, EBNA-2, LMP-1, LMP-2 Among Vietnamese Patients with Nasopharyngeal Brush Samples
por: Lao, Thuan Duc, et al.
Publicado: (2017)

EBV-Encoded LMP1 Upregulates Igκ 3′Enhancer Activity and Igκ Expression in Nasopharyngeal Cancer Cells by Activating the Ets-1 through ERKs Signaling
por: Liu, Haidan, et al.
Publicado: (2012)

Positive regulation of TAZ expression by EBV-LMP1 contributes to cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma
por: He, Jiang, et al.
Publicado: (2016)

The Anti-Apoptotic Role of EBV-LMP1 in Lymphoma Cells
por: Zeng, Mei, et al.
Publicado: (2020)

EBV-driven LMP1 and IFN-γ up-regulate PD-L1 in nasopharyngeal carcinoma: Implications for oncotargeted therapy
por: Fang, Wenfeng, et al.
Publicado: (2014)

Role of p90RSK in Kidney and Other Diseases
por: Lin, Ling, et al.
Publicado: (2019)

Molecular Screening of Nasopharyngeal Carcinoma: Detection of LMP-1, LMP-2 Gene Expression in Vietnamese Nasopharyngeal Swab Samples
por: Lao, Thuan Duc, et al.
Publicado: (2019)

ERK1/2-RSK regulation of oestrogen homeostasis
por: Wright, Eric B., et al.
Publicado: (2023)

Generation of affibody molecules specific for HPV16 E7 recognition
por: Xue, Xiangyang, et al.
Publicado: (2016)

Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation
por: Vu, Hang Thi, et al.
Publicado: (2018)

Interleukins, laminin and epstein - barr virus latent membrane protein 1 (EBV LMP1) Promote metastatic phenotype in nasopharyngeal carcinoma
por: Chew, Michelle MS, et al.
Publicado: (2010)

Radiation therapy induces immunosenescence mediated by p90RSK
por: Imanishi, Masaki, et al.
Publicado: (2022)

Serum EBV antibodies and LMP-1 in Polish patients with oropharyngeal and laryngeal cancer
por: Fołtyn, Sylwia, et al.
Publicado: (2017)

Correction: Yang L, et al., “Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity”, Cancer Biol Ther 2014; 15:61–8
por: Yang, Lifang, et al.
Publicado: (2014)

The EBV-encoded Latent Membrane Proteins, LMP2A and LMP2B, Limit the Actions of Interferon by Targeting Interferon Receptors for Degradation
por: Shah, Khilan M., et al.
Publicado: (2009)

p90Rsk is not involved in cytostatic factor arrest in mouse oocytes
por: Dumont, Julien, et al.
Publicado: (2005)

The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy
por: Lo, Angela Kwok-Fung, et al.
Publicado: (2021)

Quetiapine and aripiprazole signal differently to ERK, p90RSK and c-Fos in mouse frontal cortex and striatum: role of the EGF receptor
por: Pereira, Avril, et al.
Publicado: (2014)

Artemether confers neuroprotection on cerebral ischemic injury through stimulation of the Erk1/2-P90rsk-CREB signaling pathway
por: Li, Shuai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ce599t1n2c09845idd0hctkdth