Impact of aza-substitutions on the preference of helix handedness for β-peptide oligomers: a DFT study

We studied the helix preference of the heterochiral pentamers of cis-2-aminocyclohexanecarboxylic acid (c-ACHC) and cis-2-aminocyclopentanecarboxylic acid (c-ACPC) with alternating backbone configurations by replacing C(β)-aza- or C(α)-aza-peptide residues using DFT methods in solution. The helix-ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Hae Sook, Kang, Young Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850699/
https://www.ncbi.nlm.nih.gov/pubmed/36756412
http://dx.doi.org/10.1039/d2ra07575j
Descripción
Sumario:We studied the helix preference of the heterochiral pentamers of cis-2-aminocyclohexanecarboxylic acid (c-ACHC) and cis-2-aminocyclopentanecarboxylic acid (c-ACPC) with alternating backbone configurations by replacing C(β)-aza- or C(α)-aza-peptide residues using DFT methods in solution. The helix-handedness preferences of two pentamers were strongly affected by the replacement positions (i.e., chiralities) but not depending on the solvent polarity.

Ejemplares similares