Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins

[Image: see text] A challenge for design of protein–small-molecule recognition is that incorporation of cavities with size, shape, and composition suitable for specific recognition can considerably destabilize protein monomers. This challenge can be overcome through binding pockets formed at homo-ol...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerben, Stacey R, Borst, Andrew J, Hicks, Derrick R, Moczygemba, Isabelle, Feldman, David, Coventry, Brian, Yang, Wei, Bera, Asim K., Miranda, Marcos, Kang, Alex, Nguyen, Hannah, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850923/
https://www.ncbi.nlm.nih.gov/pubmed/36627259
http://dx.doi.org/10.1021/acs.biochem.2c00497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850923/
https://www.ncbi.nlm.nih.gov/pubmed/36627259
http://dx.doi.org/10.1021/acs.biochem.2c00497

Ejemplares similares