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Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins
[Image: see text] A challenge for design of protein–small-molecule recognition is that incorporation of cavities with size, shape, and composition suitable for specific recognition can considerably destabilize protein monomers. This challenge can be overcome through binding pockets formed at homo-ol...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850923/ https://www.ncbi.nlm.nih.gov/pubmed/36627259 http://dx.doi.org/10.1021/acs.biochem.2c00497 |