Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function

The accumulation of toxic protein aggregates in multiple neurodegenerative diseases is associated with defects in the macroautophagy/autophagy-lysosome pathway. The amelioration of disease phenotypes across multiple models of neurodegeneration can be achieved through modulating the master regulator...

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Detalles Bibliográficos
Autores principales: Carling, Phillippa J, Ryan, Brent J, McGuinness, William, Kataria, Shikha, Humble, Stewart W, Milde, Stefan, Duce, James A, Kapadia, Nirav, Zuercher, William J, Davis, John B., Di Daniel, Elena, Wade-Martins, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851200/
https://www.ncbi.nlm.nih.gov/pubmed/35786165
http://dx.doi.org/10.1080/15548627.2022.2095834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851200/
https://www.ncbi.nlm.nih.gov/pubmed/35786165
http://dx.doi.org/10.1080/15548627.2022.2095834

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