Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies

Synapses represent an important target of Alzheimer disease (AD), and alterations of their excitability are among the earliest changes associated with AD development. Synaptic activation has been shown to be protective in models of AD, and deep brain stimulation (DBS), a surgical strategy that modul...

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Detalles Bibliográficos
Autores principales: Akwa, Yvette, Di Malta, Chiara, Zallo, Fátima, Gondard, Elise, Lunati, Adele, Diaz-de-Grenu, Lara Z., Zampelli, Angela, Boiret, Anne, Santamaria, Sara, Martinez-Preciado, Maialen, Cortese, Katia, Kordower, Jeffrey H., Matute, Carlos, Lozano, Andres M., Capetillo-Zarate, Estibaliz, Vaccari, Thomas, Settembre, Carmine, Baulieu, Etienne E., Tampellini, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851246/
https://www.ncbi.nlm.nih.gov/pubmed/35867714
http://dx.doi.org/10.1080/15548627.2022.2095791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851246/
https://www.ncbi.nlm.nih.gov/pubmed/35867714
http://dx.doi.org/10.1080/15548627.2022.2095791

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