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Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings

Protein language modeling is a fast-emerging deep learning method in bioinformatics with diverse applications such as structure prediction and protein design. However, application toward estimating sequence conservation for functional site prediction has not been systematically explored. Here, we pr...

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Detalles Bibliográficos
Autores principales: Yeung, Wayland, Zhou, Zhongliang, Li, Sheng, Kannan, Natarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851297/
https://www.ncbi.nlm.nih.gov/pubmed/36631405
http://dx.doi.org/10.1093/bib/bbac599