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Alignment-free estimation of sequence conservation for identifying functional sites using protein sequence embeddings
Protein language modeling is a fast-emerging deep learning method in bioinformatics with diverse applications such as structure prediction and protein design. However, application toward estimating sequence conservation for functional site prediction has not been systematically explored. Here, we pr...
Autores principales: | Yeung, Wayland, Zhou, Zhongliang, Li, Sheng, Kannan, Natarajan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851297/ https://www.ncbi.nlm.nih.gov/pubmed/36631405 http://dx.doi.org/10.1093/bib/bbac599 |
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