The making of multivalent gamma delta TCR anti-CD3 bispecific T cell engagers

INTRODUCTION: We have recently developed a novel T cell engager concept by utilizing γ9δ2TCR as tumor targeting domain, named gamma delta TCR anti-CD3 bispecific molecule (GAB), targeting the phosphoantigen-dependent orchestration of BTN2A1 and BTN3A1 at the surface of cancer cells. GABs are made by...

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Detalles Bibliográficos
Autores principales: van Diest, Eline, Nicolasen, Mara J. T., Kramer, Lovro, Zheng, Jiali, Hernández-López, Patricia, Beringer, Dennis X., Kuball, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851377/
https://www.ncbi.nlm.nih.gov/pubmed/36685546
http://dx.doi.org/10.3389/fimmu.2022.1052090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851377/
https://www.ncbi.nlm.nih.gov/pubmed/36685546
http://dx.doi.org/10.3389/fimmu.2022.1052090

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