A role for BCL2L13 and autophagy in germline purifying selection of mtDNA

Mammalian mitochondrial DNA (mtDNA) is inherited uniparentally through the female germline without undergoing recombination. This poses a major problem as deleterious mtDNA mutations must be eliminated to avoid a mutational meltdown over generations. At least two mechanisms that can decrease the mut...

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Detalles Bibliográficos
Autores principales: Kremer, Laura S., Bozhilova, Lyuba V., Rubalcava-Gracia, Diana, Filograna, Roberta, Upadhyay, Mamta, Koolmeister, Camilla, Chinnery, Patrick F., Larsson, Nils-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851501/
https://www.ncbi.nlm.nih.gov/pubmed/36608143
http://dx.doi.org/10.1371/journal.pgen.1010573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851501/
https://www.ncbi.nlm.nih.gov/pubmed/36608143
http://dx.doi.org/10.1371/journal.pgen.1010573

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