Interdomain dynamics in human Replication Protein A regulates kinetics and thermodynamics of its binding to ssDNA

Human Replication Protein A (hRPA) is a multidomain protein that interacts with ssDNA intermediates to provide the latter much-needed stability during DNA metabolism and maintain genomic integrity. Although the ssDNA organization with hRPA was studied recently through experimental means, characteriz...

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Detalles Bibliográficos
Autores principales: Sangeeta, Bhattacherjee, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851514/
https://www.ncbi.nlm.nih.gov/pubmed/36656834
http://dx.doi.org/10.1371/journal.pone.0278396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851514/
https://www.ncbi.nlm.nih.gov/pubmed/36656834
http://dx.doi.org/10.1371/journal.pone.0278396

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