A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome

RNA modifications are widespread in biology and abundant in ribosomal RNA. However, the importance of these modifications is not well understood. We show that methylation of a single nucleotide, in the catalytic center of the large subunit, gates ribosome assembly. Massively parallel mutational scan...

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Detalles Bibliográficos
Autores principales: Yelland, James N., Bravo, Jack P. K., Black, Joshua J., Taylor, David W., Johnson, Arlen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851907/
https://www.ncbi.nlm.nih.gov/pubmed/36536102
http://dx.doi.org/10.1038/s41594-022-00891-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851907/
https://www.ncbi.nlm.nih.gov/pubmed/36536102
http://dx.doi.org/10.1038/s41594-022-00891-8

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