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A single 2′-O-methylation of ribosomal RNA gates assembly of a functional ribosome
RNA modifications are widespread in biology and abundant in ribosomal RNA. However, the importance of these modifications is not well understood. We show that methylation of a single nucleotide, in the catalytic center of the large subunit, gates ribosome assembly. Massively parallel mutational scan...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9851907/ https://www.ncbi.nlm.nih.gov/pubmed/36536102 http://dx.doi.org/10.1038/s41594-022-00891-8 |