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Visceral and emotional responses to direct electrical stimulations of the cortex

OBJECTIVE: Visceral sensations are bodily symptoms which are component manifestations of emotions frequently reported during epileptic seizures. Nowadays, the underlying mechanism and location of brain areas involved in the processing of these sensations remain unclear. Our objectives were to charac...

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Autores principales: Soulier, Hugo, Mauguière, François, Catenoix, Hélène, Montavont, Alexandra, Isnard, Jean, Hermier, Marc, Guenot, Marc, Rheims, Sylvain, Mazzola, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852394/
https://www.ncbi.nlm.nih.gov/pubmed/36424874
http://dx.doi.org/10.1002/acn3.51694
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author Soulier, Hugo
Mauguière, François
Catenoix, Hélène
Montavont, Alexandra
Isnard, Jean
Hermier, Marc
Guenot, Marc
Rheims, Sylvain
Mazzola, Laure
author_facet Soulier, Hugo
Mauguière, François
Catenoix, Hélène
Montavont, Alexandra
Isnard, Jean
Hermier, Marc
Guenot, Marc
Rheims, Sylvain
Mazzola, Laure
author_sort Soulier, Hugo
collection PubMed
description OBJECTIVE: Visceral sensations are bodily symptoms which are component manifestations of emotions frequently reported during epileptic seizures. Nowadays, the underlying mechanism and location of brain areas involved in the processing of these sensations remain unclear. Our objectives were to characterize the type and frequency of visceral and emotional responses evoked by electrical stimulations, to produce a mapping of brain structures involved in their processing, and to assess the link between visceral sensations and emotional feelings. METHODS: We reviewed 12,088 bipolar stimulations performed in 203 patients during the presurgical evaluation of drug refractory epilepsy. Responses to stimulation were divided into viscero‐sensitive, viscero‐vegetative, and emotional sensations. Univariate analysis and conditional logistic regression were used to assess the association between visceral and emotional sensations and localization of the stimulated contacts. RESULTS: In total, 543 stimulations evoked visceral and emotional sensations. Stimulations of operculo‐insulolimbic structures (amygdala, anterior and posterior insula, anterior and mid‐cingulate cortex, hippocampus, parahippocampus, temporal pole, frontal and parietal operculum) were significantly more associated with visceral and emotional sensations than all other cortical regions. Preferential implication of certain brain structures, depending on the type of visceral responses was evidenced: temporo‐mesial structures, insula, and frontoparietal operculum for viscero‐sensitive sensations; amygdala, insula, anterior and mid‐cingulate cortex, and temporal pole for viscero‐vegetative sensations; temporo‐mesial structures, anterior cingulate cortex, and frontal operculum for emotional sensations. INTERPRETATION: Our data can help to guide SEEG explorations when visceral or emotional symptoms are part of the ictal semiology. They also bring some insights into the mechanisms of visceroception and the functional significance of the co‐localization of visceral and emotional representations in the human brain.
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spelling pubmed-98523942023-01-24 Visceral and emotional responses to direct electrical stimulations of the cortex Soulier, Hugo Mauguière, François Catenoix, Hélène Montavont, Alexandra Isnard, Jean Hermier, Marc Guenot, Marc Rheims, Sylvain Mazzola, Laure Ann Clin Transl Neurol Research Articles OBJECTIVE: Visceral sensations are bodily symptoms which are component manifestations of emotions frequently reported during epileptic seizures. Nowadays, the underlying mechanism and location of brain areas involved in the processing of these sensations remain unclear. Our objectives were to characterize the type and frequency of visceral and emotional responses evoked by electrical stimulations, to produce a mapping of brain structures involved in their processing, and to assess the link between visceral sensations and emotional feelings. METHODS: We reviewed 12,088 bipolar stimulations performed in 203 patients during the presurgical evaluation of drug refractory epilepsy. Responses to stimulation were divided into viscero‐sensitive, viscero‐vegetative, and emotional sensations. Univariate analysis and conditional logistic regression were used to assess the association between visceral and emotional sensations and localization of the stimulated contacts. RESULTS: In total, 543 stimulations evoked visceral and emotional sensations. Stimulations of operculo‐insulolimbic structures (amygdala, anterior and posterior insula, anterior and mid‐cingulate cortex, hippocampus, parahippocampus, temporal pole, frontal and parietal operculum) were significantly more associated with visceral and emotional sensations than all other cortical regions. Preferential implication of certain brain structures, depending on the type of visceral responses was evidenced: temporo‐mesial structures, insula, and frontoparietal operculum for viscero‐sensitive sensations; amygdala, insula, anterior and mid‐cingulate cortex, and temporal pole for viscero‐vegetative sensations; temporo‐mesial structures, anterior cingulate cortex, and frontal operculum for emotional sensations. INTERPRETATION: Our data can help to guide SEEG explorations when visceral or emotional symptoms are part of the ictal semiology. They also bring some insights into the mechanisms of visceroception and the functional significance of the co‐localization of visceral and emotional representations in the human brain. John Wiley and Sons Inc. 2022-11-24 /pmc/articles/PMC9852394/ /pubmed/36424874 http://dx.doi.org/10.1002/acn3.51694 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Soulier, Hugo
Mauguière, François
Catenoix, Hélène
Montavont, Alexandra
Isnard, Jean
Hermier, Marc
Guenot, Marc
Rheims, Sylvain
Mazzola, Laure
Visceral and emotional responses to direct electrical stimulations of the cortex
title Visceral and emotional responses to direct electrical stimulations of the cortex
title_full Visceral and emotional responses to direct electrical stimulations of the cortex
title_fullStr Visceral and emotional responses to direct electrical stimulations of the cortex
title_full_unstemmed Visceral and emotional responses to direct electrical stimulations of the cortex
title_short Visceral and emotional responses to direct electrical stimulations of the cortex
title_sort visceral and emotional responses to direct electrical stimulations of the cortex
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852394/
https://www.ncbi.nlm.nih.gov/pubmed/36424874
http://dx.doi.org/10.1002/acn3.51694
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