Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells

Auranofin (AF), a gold (I)-containing phosphine compound, is being investigated for oncological application as a repurposed drug. We show here that 4~5 µM AF induces paraptosis, a non-apoptotic cell death mode characterized by dilation of the endoplasmic reticulum (ER) and mitochondria, in breast ca...

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Detalles Bibliográficos
Autores principales: Seo, Min Ji, Kim, In Young, Lee, Dong Min, Park, Yeon Jung, Cho, Mi-Young, Jin, Hyo Joon, Choi, Kyeong Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852458/
https://www.ncbi.nlm.nih.gov/pubmed/36658130
http://dx.doi.org/10.1038/s41419-023-05586-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852458/
https://www.ncbi.nlm.nih.gov/pubmed/36658130
http://dx.doi.org/10.1038/s41419-023-05586-6

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