Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies

Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including Pierson syndrome. We have employed cryo-electron microscopy to determine a 3.7 Å structure of the trimeric laminin polymer node containing α1, β1 and γ1 sub...

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Detalles Bibliográficos
Autores principales: Kulczyk, Arkadiusz W., McKee, Karen K., Zhang, Ximo, Bizukojc, Iwona, Yu, Ying Q., Yurchenco, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852560/
https://www.ncbi.nlm.nih.gov/pubmed/36658135
http://dx.doi.org/10.1038/s41467-023-36077-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852560/
https://www.ncbi.nlm.nih.gov/pubmed/36658135
http://dx.doi.org/10.1038/s41467-023-36077-z

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