Cargando…

Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies

Laminin polymerization is the major step in basement membranes assembly. Its failures cause laminin N-terminal domain lamininopathies including Pierson syndrome. We have employed cryo-electron microscopy to determine a 3.7 Å structure of the trimeric laminin polymer node containing α1, β1 and γ1 sub...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kulczyk, Arkadiusz W., McKee, Karen K., Zhang, Ximo, Bizukojc, Iwona, Yu, Ying Q., Yurchenco, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852560/ https://www.ncbi.nlm.nih.gov/pubmed/36658135 http://dx.doi.org/10.1038/s41467-023-36077-z

Ejemplares similares

Artificial intelligence and the analysis of cryo-EM data provide structural insight into the molecular mechanisms underlying LN-lamininopathies
por: Kulczyk, Arkadiusz W.
Publicado: (2023)

Amelioration of muscle and nerve pathology of Lama2-related dystrophy by AAV9-laminin-αLN linker protein
por: McKee, Karen K., et al.
Publicado: (2022)

Chimeric protein identification of dystrophic, Pierson and other laminin polymerization residues
por: McKee, Karen K., et al.
Publicado: (2018)

Laminin Polymerization Induces a Receptor–Cytoskeleton Network
por: Colognato, Holly, et al.
Publicado: (1999)

Exogenous laminin exhibits a unique vascular pattern in the brain via binding to dystroglycan and integrins
por: Ruan, Jingsong, et al.
Publicado: (2022)

Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction
por: Kulczyk, Arkadiusz W., et al.
Publicado: (2022)

Laminin–sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts
por: Li, Shaohua, et al.
Publicado: (2005)

Laminins in basement membrane assembly
por: Hohenester, Erhard, et al.
Publicado: (2013)

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
por: Benoit, Matthieu P.M.H., et al.
Publicado: (2018)

Distinct functions of the laminin β LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila
por: Hollfelder, Dominik, et al.
Publicado: (2014)

Author Correction: Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s
por: Benoit, Matthieu P. M. H., et al.
Publicado: (2018)

Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport
por: Mendez, Deanna L., et al.
Publicado: (2021)

Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM
por: Rawson, Shaun, et al.
Publicado: (2018)

Exploring the Structural Variability of Dynamic Biological Complexes by Single-Particle Cryo-Electron Microscopy
por: DiIorio, Megan C., et al.
Publicado: (2022)

Novel Artificial Intelligence-Based Approaches for Ab Initio Structure Determination and Atomic Model Building for Cryo-Electron Microscopy
por: DiIorio, Megan C., et al.
Publicado: (2023)

Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-Å resolution
por: Min, Guangwei, et al.
Publicado: (2006)

Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation
por: Ilangovan, Aravindan, et al.
Publicado: (2017)

Linker Protein Repair of LAMA2 Dystrophic Neuromuscular Basement Membranes
por: Yurchenco, Peter D., et al.
Publicado: (2019)

Architecture of the baculovirus nucleocapsid revealed by cryo-EM
por: Jia, Xudong, et al.
Publicado: (2023)

A Fractal Nature for Polymerized Laminin
por: Hochman-Mendez, Camila, et al.
Publicado: (2014)

A snapshot of cryo‐EM
por: Skiniotis, Georgios
Publicado: (2016)

Interpreting the cryo-EM map
por: Rosenthal, Peter B.
Publicado: (2019)

COVID-19 and cryo-EM
por: Subramaniam, Sriram
Publicado: (2020)

Cryo-EM at ACA 2022
por: Subramaniam, Sriram, et al.
Publicado: (2022)

Tools for the cryo-EM gold rush: going from the cryo-EM map to the atomistic model
por: Kim, Doo Nam, et al.
Publicado: (2017)

Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire
por: Filman, David J., et al.
Publicado: (2019)

Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals
por: Parker, Joanne L., et al.
Publicado: (2021)

Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme uptake
por: Knejski, Paweł P., et al.
Publicado: (2023)

Cryo-EM reveals the asymmetric assembly of squid hemocyanin
por: Tanaka, Yoshikazu, et al.
Publicado: (2019)

Atomic structure of Lanreotide nanotubes revealed by cryo-EM
por: Pieri, Laura, et al.
Publicado: (2022)

CryoEM Reveals the Complexity and Diversity of ATP Synthases
por: Courbon, Gautier M., et al.
Publicado: (2022)

Polymeric nanocomposites loaded with fluoridated hydroxyapatite Ln(3+) (Ln = Eu or Tb)/iron oxide for magnetic targeted cellular imaging
por: Pan, Jie, et al.
Publicado: (2015)

Exploring applications of crowdsourcing to cryo-EM
por: Bruggemann, Jacob, et al.
Publicado: (2018)

Cryo-EM Structure of the Exocyst Complex
por: Mei, Kunrong, et al.
Publicado: (2018)

Density modification of cryo-EM maps
por: Terwilliger, Thomas C., et al.
Publicado: (2020)

Fast multiscale reconstruction for Cryo-EM()
por: Donati, Laurène, et al.
Publicado: (2018)

Cryo‐EM targets in CASP14
por: Cragnolini, Tristan, et al.
Publicado: (2021)

Cryo-EM structure of the SEA complex
por: Tafur, Lucas, et al.
Publicado: (2022)

Cryo‐EM structures of coagulation factors
por: Di Cera, Enrico, et al.
Publicado: (2022)

AlphaFold2 and CryoEM: Revisiting CryoEM modeling in near-atomic resolution density maps
por: Hryc, Corey F., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m679ba113ncpacgu3at4o0phom