Step-dose IL-7 treatment promotes systemic expansion of T cells and alters immune cell landscape in blood and lymph nodes

We employed a dose-escalation regimen in rhesus macaques to deliver glycosylated IL-7, a cytokine critical for development and maintenance of T lymphocytes. IL-7 increased proliferation and survival of T cells and triggered several chemokines and cytokines. Induction of CXCL13 in lymph nodes (LNs) l...

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Detalles Bibliográficos
Autores principales: Pandit, Hrishikesh, Valentin, Antonio, Angel, Matthew, Deleage, Claire, Bergamaschi, Cristina, Bear, Jenifer, Sowder, Raymond, Felber, Barbara K., Pavlakis, George N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852696/
https://www.ncbi.nlm.nih.gov/pubmed/36685042
http://dx.doi.org/10.1016/j.isci.2023.105929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852696/
https://www.ncbi.nlm.nih.gov/pubmed/36685042
http://dx.doi.org/10.1016/j.isci.2023.105929

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