Bispecific killer cell engager with high affinity and specificity toward CD16a on NK cells for cancer immunotherapy

INTRODUCTION: The Fc region of monoclonal antibodies (mAbs) interacts with the CD16a receptor on natural killer (NK) cells with “low affinity” and “low selectivity”. This low affinity/selectivity interaction results in not only suboptimal anticancer activity but also induction of adverse effects. CD...

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Detalles Bibliográficos
Autores principales: Nikkhoi, Shahryar Khoshtinat, Li, Geng, Eleya, Suha, Yang, Ge, Vandavasi, Venu Gopal, Hatefi, Arash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852913/
https://www.ncbi.nlm.nih.gov/pubmed/36685519
http://dx.doi.org/10.3389/fimmu.2022.1039969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9852913/
https://www.ncbi.nlm.nih.gov/pubmed/36685519
http://dx.doi.org/10.3389/fimmu.2022.1039969

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