Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review

OBJECTIVE: Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade cancer that was included from the 4th edition of WHO classification of head and neck tumours. The purpose of this study is to analyse clinical behaviour, pattern of recurrences and survival outcomes of this neoplasm. METHODS: Retro...

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Autores principales: Turri-Zanoni, Mario, Dalfino, Gianluca, Lechner, Matt, Dallan, Iacopo, Battaglia, Paolo, Facco, Carla, Franzi, Francesca, Gravante, Giacomo, Ferrari, Marco, Terzakis, Dimitrios, Jay, Amrita, Forster, Martin D., Ambrosoli, Andrea Luigi, Bignami, Maurizio, Georgalas, Christos, Herman, Philippe, Nicolai, Piero, Lund, Valerie J., Castelnuovo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore Srl 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853106/
https://www.ncbi.nlm.nih.gov/pubmed/36654521
http://dx.doi.org/10.14639/0392-100X-N2087
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author Turri-Zanoni, Mario
Dalfino, Gianluca
Lechner, Matt
Dallan, Iacopo
Battaglia, Paolo
Facco, Carla
Franzi, Francesca
Gravante, Giacomo
Ferrari, Marco
Terzakis, Dimitrios
Jay, Amrita
Forster, Martin D.
Ambrosoli, Andrea Luigi
Bignami, Maurizio
Georgalas, Christos
Herman, Philippe
Nicolai, Piero
Lund, Valerie J.
Castelnuovo, Paolo
author_facet Turri-Zanoni, Mario
Dalfino, Gianluca
Lechner, Matt
Dallan, Iacopo
Battaglia, Paolo
Facco, Carla
Franzi, Francesca
Gravante, Giacomo
Ferrari, Marco
Terzakis, Dimitrios
Jay, Amrita
Forster, Martin D.
Ambrosoli, Andrea Luigi
Bignami, Maurizio
Georgalas, Christos
Herman, Philippe
Nicolai, Piero
Lund, Valerie J.
Castelnuovo, Paolo
author_sort Turri-Zanoni, Mario
collection PubMed
description OBJECTIVE: Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade cancer that was included from the 4th edition of WHO classification of head and neck tumours. The purpose of this study is to analyse clinical behaviour, pattern of recurrences and survival outcomes of this neoplasm. METHODS: Retrospective review of patients affected by BSNS who were treated via an endoscopic-assisted approach in 6 European tertiary-care referral hospitals. Cases of BSNS described in literature since 2012 to date were fully reviewed, according to PRISMA guidelines. RESULTS: A total of 15 patients were included. Seven patients were treated via an endoscopic endonasal approach, 4 with endoscopic transnasal craniectomy, and 4 via a cranio-endoscopic approach. Adjuvant treatment was delivered in 2 cases. After a mean follow-up of 27.3 months, systemic metastasis was observed in 1 case; the 5-year overall survival and disease-free survival rates were 100% and 80 ± 17.9%, respectively. CONCLUSIONS: BSNS is a locally aggressive tumour with a low recurrence rate and encouraging survival outcomes if properly treated with surgical resection and free margins followed by adjuvant radiotherapy for selected cases. Endoscopic-assisted surgery is safe and effective as an upfront treatment within a multidisciplinary care protocol.
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spelling pubmed-98531062023-02-08 Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review Turri-Zanoni, Mario Dalfino, Gianluca Lechner, Matt Dallan, Iacopo Battaglia, Paolo Facco, Carla Franzi, Francesca Gravante, Giacomo Ferrari, Marco Terzakis, Dimitrios Jay, Amrita Forster, Martin D. Ambrosoli, Andrea Luigi Bignami, Maurizio Georgalas, Christos Herman, Philippe Nicolai, Piero Lund, Valerie J. Castelnuovo, Paolo Acta Otorhinolaryngol Ital Rhinology OBJECTIVE: Biphenotypic sinonasal sarcoma (BSNS) is a rare low-grade cancer that was included from the 4th edition of WHO classification of head and neck tumours. The purpose of this study is to analyse clinical behaviour, pattern of recurrences and survival outcomes of this neoplasm. METHODS: Retrospective review of patients affected by BSNS who were treated via an endoscopic-assisted approach in 6 European tertiary-care referral hospitals. Cases of BSNS described in literature since 2012 to date were fully reviewed, according to PRISMA guidelines. RESULTS: A total of 15 patients were included. Seven patients were treated via an endoscopic endonasal approach, 4 with endoscopic transnasal craniectomy, and 4 via a cranio-endoscopic approach. Adjuvant treatment was delivered in 2 cases. After a mean follow-up of 27.3 months, systemic metastasis was observed in 1 case; the 5-year overall survival and disease-free survival rates were 100% and 80 ± 17.9%, respectively. CONCLUSIONS: BSNS is a locally aggressive tumour with a low recurrence rate and encouraging survival outcomes if properly treated with surgical resection and free margins followed by adjuvant radiotherapy for selected cases. Endoscopic-assisted surgery is safe and effective as an upfront treatment within a multidisciplinary care protocol. Pacini Editore Srl 2022-12-31 2022-12 /pmc/articles/PMC9853106/ /pubmed/36654521 http://dx.doi.org/10.14639/0392-100X-N2087 Text en Società Italiana di Otorinolaringoiatria e Chirurgia Cervico-Facciale, Rome, Italy https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license. The article can be used by giving appropriate credit and mentioning the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Rhinology
Turri-Zanoni, Mario
Dalfino, Gianluca
Lechner, Matt
Dallan, Iacopo
Battaglia, Paolo
Facco, Carla
Franzi, Francesca
Gravante, Giacomo
Ferrari, Marco
Terzakis, Dimitrios
Jay, Amrita
Forster, Martin D.
Ambrosoli, Andrea Luigi
Bignami, Maurizio
Georgalas, Christos
Herman, Philippe
Nicolai, Piero
Lund, Valerie J.
Castelnuovo, Paolo
Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review
title Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review
title_full Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review
title_fullStr Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review
title_full_unstemmed Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review
title_short Biphenotypic sinonasal sarcoma: European multicentre case-series and systematic literature review
title_sort biphenotypic sinonasal sarcoma: european multicentre case-series and systematic literature review
topic Rhinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853106/
https://www.ncbi.nlm.nih.gov/pubmed/36654521
http://dx.doi.org/10.14639/0392-100X-N2087
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