Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma

BACKGROUND: Cell therapies for solid tumors are thwarted by the hostile tumor microenvironment (TME) and by heterogeneous expression of tumor target antigens. We address both limitations with a novel class of chimeric antigen receptors based on plant lectins, which recognize the aberrant sugar resid...

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Detalles Bibliográficos
Autores principales: McKenna, Mary K, Ozcan, Ada, Brenner, Daniel, Watanabe, Norihiro, Legendre, Maureen, Thomas, Dafydd G, Ashwood, Christopher, Cummings, Richard D, Bonifant, Challice, Markovitz, David M, Brenner, Malcolm K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853244/
https://www.ncbi.nlm.nih.gov/pubmed/36653070
http://dx.doi.org/10.1136/jitc-2022-005891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853244/
https://www.ncbi.nlm.nih.gov/pubmed/36653070
http://dx.doi.org/10.1136/jitc-2022-005891

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