High-Depth PRNP Sequencing in Brains With Sporadic Creutzfeldt-Jakob Disease

BACKGROUND AND OBJECTIVES: Sporadic Creutzfeldt-Jakob disease (sCJD) has established genetic risk factors, but, in contrast to genetic and acquired CJD, the initial trigger for misfolded prion aggregation and spread is not known. In this study, we tested the hypotheses that pathologic somatic varian...

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Detalles Bibliográficos
Autores principales: Murley, Alexander G., Nie, Yu, Golder, Zoe, Keogh, Michael John, Smith, Colin, Ironside, James W., Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853313/
https://www.ncbi.nlm.nih.gov/pubmed/36686280
http://dx.doi.org/10.1212/NXG.0000000000200054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853313/
https://www.ncbi.nlm.nih.gov/pubmed/36686280
http://dx.doi.org/10.1212/NXG.0000000000200054

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