CAR-T Cell–Mediated B-Cell Depletion in Central Nervous System Autoimmunity

BACKGROUND AND OBJECTIVES: Anti-CD20 monoclonal antibody (mAb) B-cell depletion is a remarkably successful multiple sclerosis (MS) treatment. Chimeric antigen receptor (CAR)-T cells, which target antigens in a non-major histocompatibility complex (MHC)–restricted manner, can penetrate tissues more t...

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Detalles Bibliográficos
Autores principales: Gupta, Sasha, Simic, Milos, Sagan, Sharon A., Shepherd, Chanelle, Duecker, Jason, Sobel, Raymond A., Dandekar, Ravi, Wu, Gregory F., Wu, Wesley, Pak, John E., Hauser, Stephen L., Lim, Wendell, Wilson, Michael R., Zamvil, Scott S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853314/
https://www.ncbi.nlm.nih.gov/pubmed/36657993
http://dx.doi.org/10.1212/NXI.0000000000200080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853314/
https://www.ncbi.nlm.nih.gov/pubmed/36657993
http://dx.doi.org/10.1212/NXI.0000000000200080

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