Potent Platinum(IV) Prodrugs That Incorporate a Biotin Moiety to Selectively Target Cancer Cells

Four platinum(IV) prodrugs incorporating a biotin moiety to selectively target cancer cells were synthesised, characterised, and their biological activity assessed. All complexes exhibited exceptional in vitro cytotoxicity against a panel of cancer cell lines, with [Pt(5,6-dimethyl-1,10-phenanthroli...

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Detalles Bibliográficos
Autores principales: Khoury, Aleen, Sakoff, Jennette A., Gilbert, Jayne, Karan, Shawan, Gordon, Christopher P., Aldrich-Wright, Janice R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853328/
https://www.ncbi.nlm.nih.gov/pubmed/36559273
http://dx.doi.org/10.3390/pharmaceutics14122780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853328/
https://www.ncbi.nlm.nih.gov/pubmed/36559273
http://dx.doi.org/10.3390/pharmaceutics14122780

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