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Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review

Immune checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA4) and anti-programmed death cell protein 1 (anti-PD-1), are increasingly prescribed in metastatic carcinoma therapy. ICI-related kidney injury is gradually recognized by clinicians. However, im...

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Autores principales: Li, Jun, Yu, Ya-Fen, Qi, Xiao-Wei, Du, Yuan, Li, Chun-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853439/
https://www.ncbi.nlm.nih.gov/pubmed/36685488
http://dx.doi.org/10.3389/fimmu.2022.1051577
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author Li, Jun
Yu, Ya-Fen
Qi, Xiao-Wei
Du, Yuan
Li, Chun-Qing
author_facet Li, Jun
Yu, Ya-Fen
Qi, Xiao-Wei
Du, Yuan
Li, Chun-Qing
author_sort Li, Jun
collection PubMed
description Immune checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA4) and anti-programmed death cell protein 1 (anti-PD-1), are increasingly prescribed in metastatic carcinoma therapy. ICI-related kidney injury is gradually recognized by clinicians. However, immune-related ureteritis and cystitis easily go undiagnosed. We report three cases of PD-1 monoclonal antibody (mAb)-related ureteritis and cystitis. We further carried out a review of the literature about ICI-related ureteritis and cystitis. The cases in our reports manifest urinary irritation, sterile pyuria, gross hematuria, hydronephrosis, dilation of the ureters, and acute kidney injury. Urinary irritation improved effectively; urinalysis and renal function returned to normal after glucocorticoid therapy. During ICI therapy, urinalysis and renal function and urinary imaging examination are recommended to be monitored regularly. It contributes to identify immune-related ureteritis/cystitis earlier to efficiently alleviate urinary symptoms and immunologic urinary tract injury through glucocorticoid therapy while avoiding the abuse of antibiotics.
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spelling pubmed-98534392023-01-21 Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review Li, Jun Yu, Ya-Fen Qi, Xiao-Wei Du, Yuan Li, Chun-Qing Front Immunol Immunology Immune checkpoint inhibitors (ICIs), including anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA4) and anti-programmed death cell protein 1 (anti-PD-1), are increasingly prescribed in metastatic carcinoma therapy. ICI-related kidney injury is gradually recognized by clinicians. However, immune-related ureteritis and cystitis easily go undiagnosed. We report three cases of PD-1 monoclonal antibody (mAb)-related ureteritis and cystitis. We further carried out a review of the literature about ICI-related ureteritis and cystitis. The cases in our reports manifest urinary irritation, sterile pyuria, gross hematuria, hydronephrosis, dilation of the ureters, and acute kidney injury. Urinary irritation improved effectively; urinalysis and renal function returned to normal after glucocorticoid therapy. During ICI therapy, urinalysis and renal function and urinary imaging examination are recommended to be monitored regularly. It contributes to identify immune-related ureteritis/cystitis earlier to efficiently alleviate urinary symptoms and immunologic urinary tract injury through glucocorticoid therapy while avoiding the abuse of antibiotics. Frontiers Media S.A. 2023-01-06 /pmc/articles/PMC9853439/ /pubmed/36685488 http://dx.doi.org/10.3389/fimmu.2022.1051577 Text en Copyright © 2023 Li, Yu, Qi, Du and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Jun
Yu, Ya-Fen
Qi, Xiao-Wei
Du, Yuan
Li, Chun-Qing
Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review
title Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review
title_full Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review
title_fullStr Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review
title_full_unstemmed Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review
title_short Immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: Case report and literature review
title_sort immune-related ureteritis and cystitis induced by immune checkpoint inhibitors: case report and literature review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853439/
https://www.ncbi.nlm.nih.gov/pubmed/36685488
http://dx.doi.org/10.3389/fimmu.2022.1051577
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