Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation

Hearing loss caused by the death of cochlear hair cells (HCs) might be restored through regeneration from supporting cells (SCs) via dedifferentiation and proliferation, as observed in birds. In a previous report, ERBB2 activation in a subset of cochlear SCs promoted widespread down-regulation of SO...

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Detalles Bibliográficos
Autores principales: Piekna-Przybylska, Dorota, Na, Daxiang, Zhang, Jingyuan, Baker, Cameron, Ashton, John M., White, Patricia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853549/
https://www.ncbi.nlm.nih.gov/pubmed/36687526
http://dx.doi.org/10.3389/fncel.2022.1096872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853549/
https://www.ncbi.nlm.nih.gov/pubmed/36687526
http://dx.doi.org/10.3389/fncel.2022.1096872

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