Ultrahigh-Throughput Directed Evolution of a Metal-Free α/β-Hydrolase with a Cys-His-Asp Triad into an Efficient Phosphotriesterase

[Image: see text] Finding new mechanistic solutions for biocatalytic challenges is key in the evolutionary adaptation of enzymes, as well as in devising new catalysts. The recent release of man-made substances into the environment provides a dynamic testing ground for observing biocatalytic innovati...

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Detalles Bibliográficos
Autores principales: Schnettler, J. David, Klein, Oskar James, Kaminski, Tomasz S., Colin, Pierre-Yves, Hollfelder, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853848/
https://www.ncbi.nlm.nih.gov/pubmed/36583539
http://dx.doi.org/10.1021/jacs.2c10673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853848/
https://www.ncbi.nlm.nih.gov/pubmed/36583539
http://dx.doi.org/10.1021/jacs.2c10673

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