E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance

[Image: see text] Targeted protein degradation (TPD) is a new pharmacology based on small-molecule degraders that induce proximity between a protein of interest (POI) and an E3 ubiquitin ligase. Of the approximately 600 E3s encoded in the human genome, only around 2% can be co-opted with degraders....

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Detalles Bibliográficos
Autores principales: Hanzl, Alexander, Barone, Eleonora, Bauer, Sophie, Yue, Hong, Nowak, Radosław P., Hahn, Elisa, Pankevich, Eugenia V., Koren, Anna, Kubicek, Stefan, Fischer, Eric S., Winter, Georg E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853857/
https://www.ncbi.nlm.nih.gov/pubmed/36602777
http://dx.doi.org/10.1021/jacs.2c10784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9853857/
https://www.ncbi.nlm.nih.gov/pubmed/36602777
http://dx.doi.org/10.1021/jacs.2c10784

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